Elizabeth Comstock is a fictional character from the video game BioShock Infinite. Her full name is Anna DeWitt.

The game takes place in 1912 in the floating steampunk city of Columbia, which is based on the principles of American exceptionalism. Elizabeth was raised in a controlled environment so that she would take over the city after the death of its current leader, Father Zachary Hale Comstock.

Elizabeth has the ability to open "rifts" in the fabric of reality. She is able to see every event in all infinite timelines simultaneously and effortlessly open doors to them, gaining access to parallel universes.

The character is based on Anna Moleva.