In the alternate reality known as the Age of Apocalypse (Earth-295), Rogue, whose full name is Anna Marie Lehnsherr, is a prominent member of the X-Men led by Magneto. She first appeared in X-Men: Alpha #1 (February 1995), as part of Marvel Comics' crossover event created by writers Scott Lobdell, Mark Waid, and others, with artists including Roger Cruz and Andy Kubert. Discovered wandering amnesiac in Alabama by Mystique after a confrontation in which she permanently absorbed the powers and memories of the mutant Polaris, Rogue was recruited into Magneto's resistance against Apocalypse's dystopian rule. Delivered to the X-Men's Wundagore base, she vowed to honor the dying Scarlet Witch's request to care for Magneto, eventually developing a profound romantic relationship with him, enabled by their complementary magnetic abilities allowing safe physical contact; the couple married and had a son named Charles Lehnsherr.

Rogue retains her core mutant ability to absorb life forces, powers, memories, and personalities through skin-to-skin contact, often with debilitating effects on her victims. Her permanent absorption of Polaris's magnetism grants her manipulation of magnetic fields, which she employs to enhance her superhuman strength and durability, achieve flight by repelling against the Earth's magnetic forces, and augment combat effectiveness. This magnetic prowess negates her absorption curse when interacting with Magneto, providing a rare opportunity for intimacy. Rogue demonstrates exceptional hand-to-hand combat skills and tactical leadership, making her one of the X-Men's most reliable and formidable operatives in battles against Apocalypse's forces, including the Infinites and Horsemen.

Throughout the Age of Apocalypse storyline, Rogue evolves from a conflicted newcomer—briefly involved romantically with Gambit before prioritizing Magneto—to a devoted partner, mother, and co-leader of the X-Men. She undertakes critical missions, such as halting cullings in Chicago, confronting Holocaust, and leading a rescue operation in Apocalypse's New York stronghold to save her kidnapped son by defeating the traitor Guido. In the climactic confrontation, she supports Magneto in dismantling Apocalypse's regime. Subsequent stories in Earth-295, including the 2005 anniversary miniseries and later arcs, depict her continued efforts to rebuild a post-apocalyptic world alongside Magneto, facing threats like the Celestials and a corrupted Weapon X, culminating in her tragic death beside her husband while defending humanity's remnants.