My regular settings (PDXL):

Clip Skip 2
Sampler: Euler a / DPM ++3M SDE (SGM Uniform)
Steps: 30-40
Hires.fix: x1.5
Upscaler: 8x_NMKD-Superscale_150000_G for realism or R-ESRGAN 4x+ Anime6B for illustrations (Denoising strenght 0.2-0.3)
Hires steps: 15
Never use Face Restoration!
If you want better faces just use AutoChar or AfterDetailer.

Please note that tags "3D, REALISTIC" in positive or negative may change look of your images significantly.