For best outputs:

Sampler: sampler choice becomes more a factor. Use DPM++ type samplers if you want cartoony styles, or Euler/Heun type (which includes Restart) samplers for photorealistic.

Steps: Any, cfg any, CLIP skip 2.

VAE: not necessary.

This model can work well with empty negs, unless there is something in particular u really dont want to see.

Note: This model listens to prompt a lot better (some prompts won't work anymore because it might listen too well), so be clear and chose ur words carefully.