Please consider using my new multipurpose workflow here

https://civarchive.com/models/1864291

Wan 2.2 T2V GGUF workflow, set up for use with the 4 Steps Lora.

(please download here https://huggingface.co/Kijai/WanVideo_comfy/tree/main/Wan22-Lightning)

Includes upscaling, interpolation, output of first and last frame and VRAM / Cache clearing.

Disable (right click -> Bypass) the "Rife" node and "Upscale using model" node if you are on low VRAM or don't want to use those features.

If you don't have Sage Attention installed, then disable the two SageAttention nodes as well.

(You really should install SageAttention for the speed boost tho)

Try using it with my Wan 2.2 T2V Cartoon Lora:

https://civarchive.com/models/1862320?modelVersionId=2107735