If you like characters with different eye colors you would likely get one big problem.

Sometimes the eye colors are opposite!!!

Apparently AI models don't do well with left and right. Especially for body parts it requires extra context. So image generation is hit or miss for character with heterochromia.

Here is a workflow to accurately generate it. Enable Eyes Edit in Quick Access when you found the seed you are using gives wrong colors, but you don't want to reroll because you like the composition.

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Modified Anima t2i workflow for one specific task:

Generating Character With Heterochromia while fixing wrong color.

Features:

• All features from my base workflow https://civarchive.com/models/2742675

• SAM3 detection

• Anima Edit to fix eye colors

Custom nodes used (not shown in "In Workflow" inside the Node Manager):

• Anima Sampler: https://github.com/KeithZ117/Comfyui-anima-sampler

• Anima-Artist-Mixer: https://github.com/An1X3R/Anima-Artist-Mixer

• ComfyUI-Anima-LLLite: https://github.com/kohya-ss/ComfyUI-Anima-LLLite

• ComfyUI-MooshieTiledDiffusion: https://github.com/Mooshieblob1/ComfyUI-MooshieTiledDiffusion

• ComfyUI-KJNodes: https://github.com/kijai/ComfyUI-KJNodes

• comfyui-upscale-by-model: https://github.com/cdzcj/comfyui-upscale-by-model/
  (Node Manager links to wrong repository.)

Some of these may not install properly through the Node Manager, so you might need to download and place them manually into the custom nodes folder.